理解导致创伤性脑损伤相关痴呆症的细胞机制方面的博士研究生岗位

该项目旨在探究反复遭受轻度创伤性脑损伤（TBI）后记忆衰退及痴呆症背后的分子与细胞机制。通过使用小鼠模型以及单核转录组学与电生理学等技术，本研究旨在揭示与认知障碍相关的海马区神经炎症及功能变化。

Join Us!: Repeated mild head injuries, the kind sustained by athletes, veterans, and victims of domestic violence, are increasingly linked to long-term memory problems and a higher risk of dementia later in life. Strikingly, these lasting effects can occur even when no visible brain damage is present. Yet, we still don't understand how repeated injury leads to memory decline, and there are currently no treatments that address these long-term cognitive consequences. In this project, our main goal is to dissect the molecular and cellular mechanisms underlying traumatic brain injury (TBI)-associated neurodegeneration, memory decline and dementia. To this end we will study how rmTBI triggers long-term neuroinflammation and cellular and functional changes in the hippocampus, leading to memory impairment, as TBI may weaken the brain’s resilience, accelerating hippocampus-related memory decline. This project is a collaboration between the ［会员专属信息］ lab at the Swammerdam Institute for Life Sciences, University of Amsterdam (UvA) and the Salta lab at the Netherlands Institute for Neuroscience (NIN). The complementary expertise and conceptual understanding of brain insult models, specifically TBI mouse models, transcriptomics, detailed analysis of cell morphology, advanced microscopy techniques, neurodegenerative diseases, adult neurogenesis analysis in human brain samples and human iPSC culture and derivation, establish an ideal conceptual and technical synergy, making our team very well-suited to identify disease mechanisms involved in neurodegenerative diseases associated with repetitive TBI. This project is funded by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Open Competition Domain Science – M2 grant and will be performed at the Swammerdam Institute for Life Sciences, University of Amsterdam. It is a follow up of our previous published work on traumatic brain injury and adult hippocampal neurogenesis: ［会员资料链接］ We welcome applications from candidates with diverse backgrounds, experiences and perspectives. This is what you will do: As a PhD candidate in our group, you will characterize the short- and long-term effects of rmTBI on the fate of resident neural stem cells in the hippocampus, including neurogenesis, astrogliogenesis, reactive astrogliosis, production of inflammatory mediators and, microglia activation, hippocampal function and memory impairment in a mouse model of repetitive TBI. Moreover, you will contribute to the identification of conserved cell populations, transcriptional programs and intercellular communication networks affected by TBI in the mouse and human hippocampus. For this, you will use an established mouse model of closed head rmTBI in combination with single-nucleus/spatial transcriptomics, cellular morphology, electrophysiology, behavioural testing, and molecular assays to identify mechanisms linking rmTBI to persistent hippocampal dysfunction and neuroinflammation. All the necessary techniques, expertise and training opportunities are available in our labs. Tasks and responsibilities: complete a PhD thesis within the official appointment duration (four years); systematically and independently designing, performing and documenting experiments ; setting up and running bioinformatic pipelines to complement experimental work; be an active and responsible member of both our research groups and discuss work with group members during departmental meetings and incorporate their feedback; taking a leading role in writing manuscripts for publication in peer-reviewed journals ; participating in PhD training programme of the University of Amsterdam and The Graduate School Neurosciences Amsterdam Rotterdam (ONWAR); assist teaching and supervision of Bachelor and Master students at the UvA. You will get the opportunity to: present results at (inter)national scientific conferences; expand your academic, professional and personal skills; contribute to science communication and outreach activities; thrive in a team that values impactful research and mutual support; combine the advantages that a collaborative project offers, such as access to state-of-the art research facilities at both the Swammerdam Institute, and to those at the Netherlands Institute for Neuroscience. You will work in this team: The Swammerdam Institute for Life Sciences (SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences. Within the Brain Plasticity group of SILS we study how our brain adapts to changes in an (often challenging) environment. We try to understand how plasticity is 'programmed', and how external factors like (early life) stress, nutrition, drugs, exercise or enrichment) can modify plasticity, and what role it plays in cognition and disorders, such as depression and dementia. Want to know more about our organisation? Read more about working at the University of Amsterdam. Are you passionate about uncovering what happens to the brain during impact, subsequent injury, and how the injury evolves, or resolves, afterwards? Then we are inviting you to join our interdisciplinary research teams to explore the long-term effects of repetitive mild traumatic brain injury (rmTBI) in both humans and mouse models. If you feel the profile fits you, and you are interested in the job, we look forward to receiving your application. You can apply online via the red button. We accept applications until and including 30 November 2026. Evaluation of candidates will begin immediately and continue until the position is filled. If you have any questions or do you require additional information? Please contact: Applications should include the following information (all files besides your cv should be submitted in one single pdf file ): a detailed CV including the months (not just years) when referring to your education and work experience; a letter of motivation; a list of specific courses and possibly publications, highlighting your training and expertise; the names and email addresses of two references who can provide letters of recommendation. A knowledge security check can be part of the selection procedure. (for details: national knowledge security guidelines ) Only complete applications received within the response period via the link below will be considered.

What we ask of you: Your experience and profile: a master’s degree in biomedical sciences with a neuroscience specialization or similar; a strong affinity and hands-on experience with experimental work with laboratory animals and/or molecular and cellular biology. Having an Article 9 certificate to work with laboratory animals is a pre-requisite; a strong (proven) interest in bioinformatics analysis of complex datasets fluent in English, both written and spoken. You are dedicated, accurate, stress-resistant, a pleasant colleague, well organized and prepared to, and capable of working at 2 different locations.

This is what we offer you: We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). The preferred starting date i s January 2027 . This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students. Based on a full-time appointment (38 hours per week) the gross monthly salary will range from €3.204 in the first year to €4.051 (scale P) in the last year . This does not include 8% holiday allowance and 8,3% year-end allowance. The UFO profile PhD candidate is applicable. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Universities of the Netherlands is applicable. Curious about our extensive secondary benefits package? You can read more about it here.