局部制剂与皮肤脂质之间的相互作用的多模式特征分析，及其对屏障功能与渗透作用的影响

该博士项目将利用拉曼光谱和脂质组学等技术，研究局部制剂对皮肤脂质组成及屏障功能的影响。研究目的是建立制剂引起的变化与皮肤渗透效果之间的关联，从而更好地评估皮肤产品性能。申请者应具备分析化学或相关领域的背景知识。

Job description: Project description: The performance of topical formulations depends on their physicochemical properties and their interactions with the skin. Stratum corneum lipids are essential to skin barrier function. Their composition and organisation can be modified by applied formulations, potentially affecting the penetration and permeation of active substances. Understanding these interactions is necessary to improve the assessment of cutaneous products and the interpretation of in vitro release and permeation tests. This doctoral project, part of the European guideSkin doctoral network, aims to characterise formulation-induced changes in skin lipids and establish their relationships with barrier function and permeation. The research will be conducted at the Faculty of Pharmacy, Université Paris-Saclay, in collaboration with LVMH Recherche and RiverD International B.V. The project will combine in vivo confocal Raman spectroscopy, Fourier-transform infrared spectroscopy, liquid chromatography–mass spectrometry-based lipidomics, line-field confocal optical coherence tomography and skin biometric measurements. These complementary methods will investigate molecular composition, lipid organisation, skin microstructure and functional properties before and after formulation application. Biological variability, including age, sex and ethnicity, will be considered in study design and data analysis. Parallel in vitro release testing (IVRT) and in vivo skin permeation testing (IVPT) will identify situations in which formulation-induced modification of the skin barrier contributes to differences between release and permeation outcomes. Chemometric and multivariate statistical methods will be used to identify informative molecular and functional descriptors and relate them to formulation performance. Expected outcomes include optimised experimental protocols, a multimodal dataset describing formulation–skin lipid interactions, and descriptors supporting the network’s predictive modelling activities. The findings will contribute to a mechanistic understanding of topical formulation performance and inform approaches relevant to the assessment of cutaneous product equivalence. The doctoral training includes industrial secondments of 15 months at LVMH Recherche in France and 3 months at RiverD in the Netherlands.

所需背景与技能： 资格要求： • 药学科学、分析化学、生物物理学、生物医学科学或相关领域的硕士学位。 • 申请者必须是博士候选人，即尚未拥有博士学位。 • 流动规则：研究人员在被聘人员所在国家不得拥有居住或开展主要活动的时间超过 12 个月，且该时间必须发生在被聘日期前 36 个月内。 所需技能： • 在分析化学、光谱学、成像技术、生物样本表征或相关实验学科领域的实际实验室经验。 • 在实验设计、定量数据分析及科学结果批判性解读方面的能力。使用科学数据分析软件的经验，以及提升化学计量学与可重复数据处理技能的意愿。 • 对皮肤屏障功能以及外用制剂与皮肤之间的相互作用有浓厚的兴趣。 • 良好的组织能力，对数据质量的重视，以及实验工作的严谨记录。能够在国际学术与工业研究团队中独立或协作工作。能够清晰地进行口头及书面表达科学发现。 • 具备出色的人际沟通技巧，能够自信且专业地与研究志愿者互动。能够适应与人类参与者密切接触的情况，并开展体内实验研究。能够轻松处理面向志愿者的实验工作，并以专业且富有同理心的态度从事人类研究。 • 要求具备英语能力，同时需具备良好的口头及书面沟通技巧。成功候选人须提供英语测试成绩（如 IELTS、TOEFL、剑桥英语考试）。若您是英语为母语国家的公民，或拥有以英语进行教学与考核的学历或学位，则可免试。 导师亦可确认申请者具备所需的英语水平。 所需英语水平：高级中级。您能够有效使用语言，并能够清晰准确地表达观点。