用于自适应多光子显微镜的可编程超快光纤激光器

该项目致力于开发可编程超快光纤激光器以用于多光子显微镜技术，从而增强脉冲特性的灵活性，进而实现深层组织成像。该项目将增益切换激光二极管与非线性光纤放大技术相结合，在提高效率的同时将光损伤降至最低，从而弥补传统超快激光的不足。申请者应具备光子学或生物医学成像方面的相关经验。

About the project This project aims to develop programmable ultrafast fibre lasers for multiphoton microscopy, enabling flexible control of pulse duration, energy and repetition rate. By combining gain-switched laser diodes with advanced nonlinear fibre amplification and pulse compression, the research will deliver versatile excitation sources for high-speed, deep-tissue imaging with improved efficiency and reduced photodamage. Multiphoton microscopy is a powerful tool for imaging biological structures deep within living tissues, enabling advances in neuroscience, cancer research and biomedical science. However, its performance is strongly influenced by the excitation laser, with conventional ultrafast laser sources often offering limited flexibility in pulse duration, energy and repetition rate. This restricts the ability to optimise excitation conditions for different imaging depths, biological samples and acquisition speeds, while minimising photodamage. This project aims to develop a new generation of programmable ultrafast fibre lasers that provide flexible, application-specific excitation for multiphoton microscopy. Combining gain-switched laser diodes, advanced nonlinear fibre amplification and pulse compression, the research will investigate new approaches to controlling pulse characteristics and temporal patterns. The objective is to establish compact, robust and cost-effective laser sources capable of delivering tailored excitation pulses while maintaining high pulse quality and reliable operation. Particular attention will be given to near-infrared wavelengths suitable for deep-tissue three-photon microscopy and to programmable pulse delivery for improving imaging efficiency. The project will bring together complementary expertise at the University of Southampton's Optoelectronics Research Centre (ORC) and the Institute for Life Sciences (IfLS) , integrating advanced photonics research with biomedical imaging requirements. Potential industrial collaborators, including NKT Photonics and AstraZeneca, could provide valuable perspectives on laser-system development, practical implementation and biomedical research needs. Expected outcomes include new knowledge of programmable nonlinear pulse amplification, experimental demonstrations of versatile fibre-laser excitation sources, and evaluation of their benefits for multiphoton imaging. By enabling laser parameters to be adapted to imaging requirements, this research could support faster acquisition, more efficient excitation and reduced photodamage, ultimately advancing biological imaging capabilities and strengthening the UK's position in photonics and life-science innovation. The School of Optoelectronics (ORC) is committed to promoting equality, diversity inclusivity as demonstrated by our Athena SWAN award. We welcome all applicants regardless of their gender, ethnicity, disability, sexual orientation or age, and will give full consideration to applicants seeking flexible working patterns and those who have taken a career break. The University has a generous maternity policy, onsite childcare facilities, and offers a range of benefits to help ensure employees’ well-being and work-life balance. The University of Southampton is committed to sustainability and has been awarded the Platinum EcoAward.

入学要求 英国2:1荣誉学位或同等国际学位。

资助：竞争性资助 学费与资助 我们为英国本土学生和国际学生提供多种资助机会。符合条件的学生可通过“地平线欧洲”学费减免，自动免除国际学生学费与英国本土学生学费之间的差额。 大学通过竞争性遴选授予的校长助学金，为遴选排名靠前的申请人支付国际学生学费与英国本土学生学费之间的差额。 本校各学院通过竞争性遴选提供的博士奖助金，通常为遴选排名靠前的申请人支付按英国本土学生标准收取的学费，并提供生活津贴。 资助采用滚动授予方式，因此请尽早申请，以尽可能增加进入资助评选的机会。 如需了解更多信息，请访问我们的研究生研究资助页面。

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