利用对细菌锌排出机制的结构性见解开发新型人类治疗药物

该项目旨在探究对抗菌金属具有抗性的肺炎链球菌转运蛋白的结构与功能，以期开发新的治疗策略。研究内容涵盖化学合成、EPR和NMR等高级光谱技术以及分子动力学模拟，需要具备化学、生物化学或生物物理学的相关知识。

Project description: This project aims to define the structure and mechanism of the S.pneumoniae transporter system that confers resistance to host antimicrobial metals, with the goal of developing a novel antimicrobial therapeutic strategy to block this pathway and thus treat human disease. The project involves chemical synthesis, protein synthesis with nonconical amino acids, innovative biochemistry, advanced spectroscopy, and high-performance computing. Key objectives encompass 1. Chemical synthesis and development of new biochemistry technologies, for example, site-specific tagging of proteins with non-canonical amino acids 2. Electron Paramagnetic Resonance (EPR) combined with e.g. NMR and CryoEM to determine structure of the target biomolecules 3. Development of Molecular Dynamics simulations to determine structure/function aided by experimental constraints from objective 2. You may work on one or more of the above objectives depending on your background. Research environment: The Australian Institute for Bioengineering and Nanotechnology (AIBN) and the School of Chemistry and Molecular Biosciences (SCMB) provide a world-class research environment with state-of-the-art facilities for biotechnology and biomedical research including wet labs and an array of advanced characterisation techniques. You will benefit from access to cutting-edge EPR infrastructure for DEER spectroscopy, the largest facility in the southern hemisphere, and powerful UQ supercomputing capabilities for Molecular Dynamics simulations. The project is funded by the National Health and Medical Research Council (NHMRC) and involves collaboration with The University of Melbourne.

优先认可教育背景： 您的申请将依据竞争机制进行评估。 我们已考虑您的： 以往学术成绩 发表记录 荣誉与奖项 就业经历。 对生物学、化学、物理或数学方面的基础知识具备一定的理解能力，将对参与该项目的研究工作有所帮助。 您将展示生物化学或生物物理学领域的学术成就以及未来的学习潜力。 具备以下其中一项相关背景或知识将非常理想：化学合成、NMR或EPR光谱技术，以及分子动力学模拟。

Scholarship: This project is supported by the Research project scholarship . Domestic applicants: This scholarship includes: living stipend of $39,220 per annum tax free (2026 rate), indexed annually tuition fees covered. International applicants: This scholarship includes: living stipend of $39,220 per annum tax free (2026 rate), indexed annually tuition fees covered. Learn more about the Research project scholarship .

申请方式： 您必须向国内申请者提交意向表达（EOI）：2026年11月20日；向国际申请者：2026年11月20日。 在您提交申请之前 核实您获得哲学博士（PhD）的资格情况。 请准备您的相关文件。 您申请时 申请时请提交针对该项目的兴趣表达文件（EOI）。您无需分别申请该项目或奖学金。如何提交兴趣表达文件 在您的 EOI 中，请填写“奖学金/资助”部分，并包含以下详细信息： 您是否申请了该公告中的项目？‘是’ 项目：‘研究项目奖学金’ 广告中列出的奖学金代码：EFFLUX-[会员信息] 奖学金广告链接：[会员链接] 提交 EOI