“调节突触以缓解阿尔茨海默病”领域的博士研究生岗位

该研究项目旨在探究在突触处调整谷氨酸受体组成如何能够缓解与年龄相关的认知衰退，并增强对阿尔茨海默病的抵抗力。研究采用分子工具和行为干预方法，同时结合电生理学和化学遗传学技术，在啮齿动物模型中评估学习与记忆能力。

Join us!: Glutamatergic synapses are critical for synaptic plasticity and memory formation. The composition of their receptors can modulate resilience and sensitivity to memory deficits, in particular those induced by amyloid beta (Aβ), a major hallmark of Alzheimer’s Disease. In this project you will investigate whether and how modifying the composition of glutamatergic receptors at synapses, using both molecular tools and behavioral interventions, can reduce age-related cognitive decline in and thereby enhance resilience to AD pathology. In addition, you will study the role of engram cell ensembles in this process. This is what you will do: You will use behavioral paradigms to assess learning and memory in a rodent model of AD. You will apply viral technologies to identify and measure the properties of synapses and engram cells and establish their role in memory. These techniques can include electrophysiology, proteomics, dendrite and spine reconstructions, chemogenetics, and memory engram-specific interventions. Tasks and responsibilities: complete and defend a PhD thesis within the official appointment duration of four years; gain knowledge of the field through literature, discussions with team members and internal lab meetings; contribute to the design of experiments, perform experiments in the lab and analyse and interpret results of these experiments; take a leading role in writing manuscripts; be an active member of the research teams at both the Swammerdam Institute for Life Sciences (UvA) and present results at (inter)national scientific meetings; participate in the Faculty of Science PhD training programme; assist in teaching and supervise Bachelor and Master’s students You will work in this team: The Faculty of Science has a student body of around 8,000, as well as 1,800 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain. ［会员专属信息］ and Kessels are respectively part of the Brain Plasticity group and the Cellular and Circuit Neuroscience group (at the Swammerdam Institute for Life Sciences (SILS) . SILS is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, the Swammerdam Institute carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences. Want to know more about our organisation? Read more about working at the University of Amsterdam. Are you interested in the neurobiological processes of learning and memory, and how we can use this knowledge to make the brain more resilient to the cognitive decline seen in Alzheimer’s disease (AD)? Then this position might be perfect for you. Join us! If you feel the profile fits you, and you are interested in the job, we look forward to receiving your application. You can apply online via the button below. We accept applications until and including 30 October 2026. If you have any questions or do you require additional information? Please contact: Applications should include the following information (all files besides your cv should be submitted in one single pdf file ): a detailed CV including the months (not just years) when referring to your education and work experience, highlighting also the tools and skills you acquired; a letter of motivation; the names and email addresses of two references who can provide letters of recommendation. A knowledge security check can be part of the selection procedure. (for details: national knowledge security guidelines) Only complete applications received within the response period via the link below will be considered. The interviews will be held in November 2026.

我们对您的要求是： 您对科学充满热情，尤其对神经生物学在学习与记忆研究方面的方法具有浓厚兴趣，并拥有相关经验更为理想。您喜欢挑战，能够将临床前啮齿动物模型研究与行为学、电生理学、分子生物学及结构分析等技术相结合开展工作。您具备良好的统计技能以及使用分子工具和数据分析的经验。您是优秀的团队成员，是一位令人愉快的同事，乐于参与跨学科科学家团队的工作。最后，您拥有出色的时间管理能力，能够按时完成项目所需的分析、报告及其他交付物。 您的经验与个人背景： 学习和记忆研究相关的工作经验。 神经科学或相关领域的理学硕士学位； 对开展动物实验的亲和度与经验； 对常见行为学和/或神经生物学技术的亲和度与经验； 良好的分析、写作与展示能力； 英语运用娴熟，无论是书面还是口语均流畅，且具备学习荷兰语的意愿（以防非荷兰母语者）

这是我们为您提供的聘用待遇： 为期4年的临时合同，每周工作38小时（初始合同为18个月，经满意评估后将延长至共4年）。该项目理想的开始日期为2027年1月4日，旨在最终完成博士论文。我们将制定一份教育计划，包括课程学习及（国际）会议参与。此外，期望您协助本科生和硕士生的教学工作。 根据全职聘用职位（每周38小时工作时间），税前月薪资在第一年为3204欧元，在最后一年为4051欧元（按P级标准计算）。此金额不包括8%的假期津贴和8.3%的年终津贴。适用于具有UFO专业背景的博士候选人。适用荷兰大学集体劳动协议。 除了薪资待遇以及科学园区的活跃且具有挑战性的工作环境外，我们还提供多种额外福利： 每年有 232 小时假期时间（按全职工作计算）； 来自教学与学习中心的多种课程需参加； 为博士学生提供的完整教育计划； 阿姆斯特丹大学学院提供的 ABP 养老金，阿姆斯特丹大学负责支付三分之二的缴费费用； 可参加课程以学习荷兰语； 如果您从国外移居，我们将协助您安排公寓或小房间的住宿问题。 您是否希望进一步了解我们完善的副业福利体系？请在此处查看。