针对不同性别的噬菌体疗法促进战伤愈合

该博士项目旨在开发用于复杂肌肉骨骼损伤的工程化噬菌体疗法，旨在对抗抗菌素耐药性并促进组织再生。将利用先进的损伤模型来评估双功能噬菌体在减少细菌存在的同时促进愈合方面的效果，重点研究性别特异性反应。

About the project This PhD will develop engineered bacteriophage therapies for complex musculoskeletal conflict wounds, addressing antimicrobial resistance alongside impaired vascular regeneration on the battlefield. Developing advanced MSK injury models, the project will test whether dual-function phages can reduce bacterial burden while promoting tissue repair, with consideration of sex-specific responses to injury and treatment success. Complex musculoskeletal (MSK) trauma is a major challenge in modern conflict, where blast and ballistic injuries can cause open fractures, extensive tissue damage, vascular disruption and contaminated wounds. Antimicrobial resistance (AMR) further complicates treatment, creating a critical need for antibiotic-independent approaches that can control infection while supporting tissue repair. This PhD will investigate sex-specific phage therapies for conflict wound healing, developing engineered bacteriophages designed to reduce bacterial burden while promoting vascularised MSK tissue regeneration. The research will address whether antimicrobial treatment and tissue repair can be targeted simultaneously on the battlefield, and whether responses vary according to biological sex. You will develop and apply advanced MSK trauma models to investigate, in real time, the interactions between bacterial infection, vascularisation and tissue repair. Methods will include: developing in vitro 3D cell and tissue human models of MSK trauma phage engineering and characterisation microbiological assays advanced imaging quantitative analysis of vascularisation a range of molecular approaches to understand mechanisms of infection and tissue regeneration. The project has strong defence relevance and links to UK priorities in conflict wounds, AMR, military medicine and female health. You will join an interdisciplinary research team spanning MSK regeneration, phage engineering, microbiology and vascular biology, with engagement with MOD and Dstl expertise, including military female health. Training opportunities will include advanced biological models, imaging, quantitative analysis and translational research, preparing you for a range of interdisciplinary careers across academia, defence and industry.

入学要求 您必须拥有以下领域的本科学位（至少为英国 2:1 荣誉学位）或其国际等效学位： 生物科学 生物医学科学 微生物学 组织工程 再生医学 或相关学科 以往在实验室中的经验，尤其是微生物学、细胞培养、分子生物学、成像或组织相关研究方面的经验将会有帮助，但并非必需，因为将提供适当的培训。

Funding: Competition funded Fees and funding For candidates looking to complete a PhD or EngD full-time we offer an enhanced tax-free stipend of up to £30k per year, along with a substantial budget for research, travel, and centre activities. CISDnS is committed to promoting equality, diversity and inclusivity. We welcome all applicants regardless of their gender, ethnicity, disability, sexual orientation or age, and will give full consideration to applicants seeking flexible working patterns and those who have taken a career break or are transitioning into a new role. The University has a generous maternity policy, onsite childcare facilities, and offers a range of benefits to help ensure employees’ well-being and work-life balance.

如何申请 请通过在线系统门户提交申请，并选择相应的选项： 学年：2027/28 您是全职还是兼职学习？ 工程与物理科学学院 搜索“复杂集成系统” 选择博士学位或工学博士学位——如果您不确定，请选择博士学位 请在申请书的第2节中注明指导老师的姓名。 申请材料应包括： 您的CV（个人简历） 2份学术推荐信 截至目前的学位课程成绩单和证书